NBR1
Template:Short description Template:Infobox gene Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.[1][2]
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[2] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.[3]
Interactions
NBR1 has been shown to interact with FEZ1.[4]
References
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Further reading
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