NAPSA
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Napsin-A is an aspartic proteinase that is encoded in humans by the NAPSA gene.[1] The name napsin comes from novel aspartic proteinase of the pepsin family.[2]
The activation peptide of an aspartic proteinase acts as an inhibitor of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.[1]
Utility
Detection of NAPSA gene expression can be used to distinguish adenocarcinomas from other forms of lung cancer.[3]
References
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Further reading
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