Mycobacterium lepraemurium

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Mycobacterium lepraemurium is a causative agent of feline leprosy.[1] It causes granulomatous lesions, characteristic of the Mycobacterium genus.Script error: No such module "Unsubst".

Description

Gram-positive, nonmotile and strongly acid-fast rods (3-5 μm long). Slightly rounded ends.

Colony characteristics

Physiology

  • Growth on inspissated 1% egg yolk medium at 30 °C - 37 °C within 4–5 weeks (using large inocula, confined to a concentrated area of the medium, egg white is inhibitory).

Pathogenesis

  • Cause of endemic disease of rats in various parts of the world, as well as feline leprosy.
  • feline leprosy is transmitted by bites from rats and other cats.
  • Disease occurs mainly in the skin and lymph nodes, causing induration, alopecia and eventual ulceration.
  • Nodular lesions, involving subcutaneous tissues, may be solitary or multiple and usually confined to the head region or the limbs. Nodules are fleshy and freely movable.
  • Surgical excision of the lesions is the preferred treatment.
  • Only the densely and uniformly stained forms appear to be infectious for animals, in contrast to the degenerate unevenly stained forms.
  • Biosafety level 2

Type strain

None specified due to difficulties in cultivation.

References

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