Mycobacterial porin
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Mycobacterial porins are a group of transmembrane beta-barrel proteins produced by mycobacteria, which allow hydrophilic nutrients to enter the bacterium.[1][2] They are located in the impermeable mycobacterial outer membrane, or mycomembrane of fast-growing mycobacteria. The mycomembrane is unique and composed of very-long chain fatty acids, mycolic acids. These proteins are structurally different from the typical porins located in the outer membrane of Gram-negative bacteria. For example, the MspA protein forms a tightly interconnected octamer with eight-fold rotation symmetry that resembles a goblet and contains a central channel. Each protein subunit contains a beta-sandwich of immunoglobulin-like topology and a beta-ribbon arm that forms an oligomeric transmembrane beta-barrel.[3]
MspA has biotechnological applications, most notably in nanopore sequencing.
References
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