Muzolimine
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Template:Short description Template:Drugbox
Muzolimine is a high-ceiling loop diuretic.[1] It is a pyrazole diuretic which was used for treatment of hypertension but was withdrawn worldwide because of severe neurological side effects.[2]
Synthesis
Rxn of (1-(3,4-dichlorophenyl)ethyl)hydrazine (1) with ethyl 3-amino-3-ethoxyacrylate (2) leads to a ring-forming two-site reaction and formation of the pyrazoline diuretic agent, muzolimine (3).
References
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- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Möller, Eike; Meng, Karl & Wehinger, Egbert et al., "Diuretisches und antihypertensives Mitel [Diuretic and antihypertensive agent]", published Script error: No such module "auto date formatter"., assigned to Bayer AGScript error: No such module "Check for unknown parameters".
- ↑ E. Möller et al., U.S. patent 3957814 (1976 to Bayer); eidem, Experientia 33, 382 (1977).
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