Monatepil
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Monatepil is a calcium channel blocker and α1-adrenergic receptor antagonist used as an antihypertensive.[1]
Synthesis
The synthesis of monatepil was first disclosed in patents filed by Dainippon Pharmaceutical.[2]
The amino group of the dihydrodibenzothiepin (1) is first reacted with the acid chloride of 4-chlorobutyric acid, to give the amide (3). This is then used to alkylate para-fluorophenylpiperazine (4) to yield monatepil.[2][3]
References
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- ↑ a b <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Hitoshi Uno, et al., "Calcium antagonist piperazine derivatives, and compositions therefor", issued Script error: No such module "auto date formatter"., assigned to Dainippon Pharmaceutical Co LtdScript error: No such module "Check for unknown parameters".
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