Moco RNA motif

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The Moco RNA motif is a conserved RNA structure [1] that is presumed to be a riboswitch that binds molybdenum cofactor or the related tungsten cofactor. Genetic experiments support the hypothesis that the Moco RNA motif corresponds to a genetic control element that responds to changing concentrations of molybdenum or tungsten cofactor.[2] As these cofactors are not available in purified form, in vitro binding assays cannot be performed. However, the genetic data, complex structure of the RNA and the failure to detect a protein involved in the regulation suggest that the Moco RNA motif corresponds to a class of riboswitches.

File:Moco riboswitch.svg
Consensus secondary structure of Moco RNAs. Layout is similar to a previously published figure.[2]

References

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