Methylprednisolone aceponate
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Methylprednisolone aceponate, or methylprednisolone acetate propionate, sold under the brand names Advantan and Avancort, is a glucocorticoid and a corticosteroid ester—specifically the C17α propionate and C21 acetate diester of methylprednisolone.[1][2][3]
In Russia and some other countries the drug is available in 4 dosage forms differing in consistency and water content: emulsion (or lotion), cream, ointment and fatty ointment.[4]
Synthesis
- methylprednisolone [83-43-2] (1)
- Triethyl orthopropionate [115-80-0] (2)
- PC13131717 (3)
- [79512-61-1] (4)
See also
References
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- ↑ Prous, J.; Castaer, J.; Methylprednisolone Aceponate. Drugs Fut 1993, 18, 2, 130.
- ↑ Sugai, S., Okazaki, T., Kajiwara, Y., Kanbara, T., Naito, Y., Yoshida, S., Akaboshi, S., Ikegami, S., Kamano, Y. (1985). "Studies on topical antiinflammatory corticosteroids. I. Syntheses and vasoconstrictive activities of 11.BETA.,17.ALPHA.,21-trihydroxy-6.ALPHA.-methyl-1,4-pregnadiene-3,20-dione 17-ester and 17,21-diester derivatives". Chemical and Pharmaceutical Bulletin. 33 (5): 1889–1898. doi:10.1248/cpb.33.1889.
- ↑ Klaus Annen, et al. U.S. patent 4587236 (1986 to Bayer Pharma AG).
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Template:Glucocorticoids and antiglucocorticoids
Template:Glucocorticoid receptor modulators