Methylethyltryptamine

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Methylethyltryptamine (MET), also known as N-methyl-N-ethyltryptamine (N,N-MET), is a psychedelic drug of the tryptamine family.[1][2] It is taken orally or via inhalation.[1][3]

The drug acts as an agonist of the serotonin 5-HT2 receptors and to a lesser extent as a serotonin releasing agent.[4] It is closely related to dimethyltryptamine (DMT) and to diethyltryptamine (DET).[5][6]

MET appears to have been first described in the literature in 1981.[7] It was only briefly mentioned in Alexander Shulgin's 1997 book TiHKAL (Tryptamines I Have Known and Loved).[1] The drug was encountered as a novel designer drug in Europe in 2014.[8]

Use and effects

MET was briefly mentioned in Alexander Shulgin's TiHKAL (Tryptamines I Have Known and Loved) and other publications, where he has stated it to be orally active as a psychedelic at doses of 80 to 100Script error: No such module "String".mg.[1][2][9] Its duration, onset, and peak were not provided.[1] The free base of MET has been reported to be active as a psychedelic via vaporization at a dose of 15Script error: No such module "String".mg per informal anecdotal reports.[9][3] Very little information is available on the effects of MET.[9] However, its effects have been reported to include hallucinations, euphoria, tactile enhancement, cognitive effects, pupil dilation, muscle cramps, teeth grinding, and increased heart rate and blood pressure.[9]

Interactions

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Pharmacology

Pharmacodynamics

MET is a serotonin 5-HT2A and 5-HT2C receptor partial agonist.[4] It shows very weak activity as an agonist of the serotonin 5-HT1A and 5-HT2B receptors.[4] In addition to acting at the serotonin 5-HT2 receptors, MET is a serotonin releasing agent with lower potency.[4] It produces the head-twitch response, a behavioral proxy of psychedelic effects, in animals.[6][4]

Chemistry

MET, also known as N-methyl-N-ethyltryptamine, is a substituted tryptamine derivative.[1][2][4] It is closely related to N,N-dimethyltryptamine (DMT) and to other N,N-dialkylated tryptamines.[1][2][4]

Analogues

Analogues of MET besides DMT include DET, DPT, DiPT, DBT, MiPT, MBT, EPT, EiPT, and PiPT, among others.[1][2] Derivatives of MET include 4-HO-MET, 5-MeO-MET, bretisilocin (5-fluoro-MET; GM-2505), and 7-F-5-MeO-MET, among others.[1][2]

History

MET appears to have first been described in the literature by 1981.[7] It was specifically mentioned in Michael Valentine Smith's Psychedelic Chemistry.[7] Subsequently, MET was briefly described in Alexander Shulgin's TiHKAL (Tryptamines I Have Known and Loved) in 1997.[1] MET was encountered as a novel designer drug in Europe in 2014.[8]

See also

References

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  1. ↑ a b c d e f g h i j Script error: No such module "citation/CS1".
  2. ↑ a b c d e f Script error: No such module "citation/CS1".
  3. ↑ a b "That's okay, you're good" MET trip report - The Vaults of Erowid
  4. ↑ a b c d e f g <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Kruegel AC, "Methods of treating mood disorders", issued Script error: No such module "auto date formatter"., assigned to Gilgamesh Pharmaceuticals Inc. Script error: No such module "Check for unknown parameters".
  5. ↑ Script error: No such module "citation/CS1".
  6. ↑ a b Script error: No such module "citation/CS1".
  7. ↑ a b c Script error: No such module "citation/CS1".
  8. ↑ a b Script error: No such module "citation/CS1".
  9. ↑ a b c d Script error: No such module "Citation/CS1".

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External links

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