Mequinol
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Mequinol, MeHQ or 4-methoxyphenol, is an organic compound with the formula Template:Chem2. It is a phenol with a methoxy group in the para position. A colorless solid, it is used in dermatology[1] and organic chemistry.[2]
Use in dermatology
Mequinol is a common active ingredient in topical drugs used for skin depigmentation. As a topical drug mequinol is often mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% mequinol and 0.01% tretinoin by mass.[1] Dermatologists commonly prescribe the drug to treat liver spots.
Lower dosages of mequinol have been used in conjunction with a Q-switched laser to depigment skin in patients with disseminated idiopathic vitiligo.[3]
Organic chemistry
In organic chemistry 4-methoxyphenol is used as a polymerisation inhibitor (e.g. acrylates or styrene monomers).[2]
4-Methoxyphenol can be produced from p-benzoquinone and methanol via a free radical reaction.[4][5]
Safety
The U.S. National Institute for Occupational Safety and Health (NIOSH) has set a recommended exposure limit (REL) of 5 mg/m3 over an 8-hour workday.[6]
See also
- Monobenzone (benzyloxyphenol)
- Hydroquinone
- Guaiacol
- 2-Hydroxy-5-methoxybenzaldehyde
References
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External links
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