Mallory body
In histopathology, a Mallory body, Mallory–Denk body (MDB), or Mallory's hyaline is an inclusion found in the cytoplasm of liver cells.[1] Mallory bodies are damaged intermediate filaments within the liver cells.
Associated conditions
Mallory bodies are classically found in the livers of people suffering from alcohol-induced liver disease and were once thought to be specific for that.[2]
They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).[3]
They are a recognized feature of Wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions.[3] However, it has also been reported in certain other unrelated conditions.[4]
Appearance
Mallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate cytokeratin 8/18 filament proteins that have been ubiquitinated, or bound by other proteins such as heat shock proteins, or p62/Sequestosome 1.[5]
Eponym
It is named for the American pathologist Frank Burr Mallory, who first described the structures in 1911.[3] A renaming as Mallory–Denk bodies was proposed in 2007 to honor the contribution of Austrian pathologist Helmut Denk for the molecular analysis of the pathogenesis of MDBs.[6]
Additional images
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Micrograph showing a Mallory body. Original magnification 400X. H&E stain.
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Micrograph showing a Mallory body. Original magnification 200X. H&E stain.
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Liver micrograph showing abundant Mallory bodies, as seen in alcohol use disorder.
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Mallory bodies in hepatocellular carcinoma. Trichrome stain.
See also
- Ballooning degeneration – another histopathologic finding of steatohepatitis
References
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