Magaldrate
Template:Short description Template:Drugbox
Magaldrate (INN) is a common antacid drug that is used for the treatment of duodenal and gastric ulcers, esophagitis from gastroesophageal reflux.
Development
Magaldrat was first synthesized by the German chemist Gunther Hallmann and patented on February 2, 1960, by Byk Gulden Lomberg Chemische Fabrik (Germany).[1] In 1983, the active substance was registered as the original drug Riopan.[2]
Available forms
Magaldrate is available in the form of oral suspension or tablets.
Pharmacology
Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly by gastric acid into Mg(OH)2 and Al(OH)3, which are absorbed poorly and thus provide a sustained antacid effect.[3]
Interactions and adverse reactions
Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.
References
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- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Hallmann G, "Process for the preparation of magnesium aluminate hydrate, and therapeutic agents so produced", issued Script error: No such module "auto date formatter"., assigned to Byk Gulden Lomberg Chem. Fab.Script error: No such module "Check for unknown parameters".
- ↑ Fachinfo Riopan Magen Tabletten, Stand Dezember 2014.
- ↑ Script error: No such module "citation/CS1".
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