Mafosfamide
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Mafosfamide (INN) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic. It is metabolized by cytochrome P450 into 4-hydroxycyclophosphamide, which is then converted into aldophosphamide, which, in turn yields the cytotoxic metabolites phosphoramide mustard and acrolein.[1]
Several Phase I trials have been completed.[2][3]
References
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- ↑ Ludeman SM. The chemistry of the metabolites of cyclophosphamide. Curr Pharm Des. 1999 Aug;5(8):627-43. Template:Catalog lookup link
- ↑ Script error: No such module "citation/CS1". ClinicalTrials.gov Identifier NCT00062881.
- ↑ Script error: No such module "citation/CS1". ClinicalTrials.gov Identifier NCT00031928.
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