Macbecin
Macbecins are a pair of chemical compounds in the ansamycin family of antibiotics. They are designated macbecin I and macbecin II and they were first isolated from actinomycete bacteria.[1][2] Macbecin possesses antitumor properties.[1] In vitro studies have shown that macbecins are effective in the eradication of Gram-positive bacteria, fungi, and protozoa including Tetrahymena pyriformis.[1]
Structure
Macbecins have an unusual macrocyclic lactam structure. The two variants, macbecin I and II, correspond to the oxidized 1,4-benzoquinone and reduced hydroquinone, respectively.[2]
Mechanism of action
Macbecins mechanism of action is in part due to heat shock protein Hsp90 protein inhibition.[3]
References
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