MYBL2

Template:Cs1 config Template:Short description Template:Infobox gene Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.

Function

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. MYBL2 is deregulated in various cancer types and can contribute to cancer progression.

Interactions

MYBL2 has been shown to interact with:

• CDK9
• CREB-binding protein
• Cyclin A1
• Cyclin-dependent kinase inhibitor 1C
• EP300
• PARP1
• Retinoblastoma-like protein 1

External links

• Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.