MODY 4
Script error: No such module "Unsubst". Template:Infobox medical condition (new) MODY 4 or PDX1-MODY is a form of maturity onset diabetes of the young.
MODY 4 arises from mutations of the PDX1 homeobox gene on chromosome 13. Pdx-1 is a transcription factor vital to the development of the embryonic pancreas. Even in adults it continues to play a role in the regulation and expression of genes for insulin, GLUT2, glucokinase, and somatostatin.
MODY 4 is so rare that only a single family has been well-studied. A child born with pancreatic agenesis (absence of the pancreas) was found to be homozygous for Pdx-1 mutations. A number of older relatives who were heterozygous had mild hyperglycemia or diabetes. None were severely insulin-deficient and all were controlled with either diet or oral hypoglycemic agents.
References
<templatestyles src="Reflist/styles.css" />
Script error: No such module "Check for unknown parameters".
External links
Template:Medical resources Template:Disease of the pancreas and glucose metabolism Template:Transcription factor/coregulator deficiencies
- ↑ Script error: No such module "Citation/CS1".