MCOLN1
Template:Short description Template:Infobox gene
Mucolipin-1 (ML1) also known as TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) is a protein that in humans is encoded by the MCOLN1 gene.[1] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.
TRPML1 is a 65 kDa protein associated with mucolipidosis type IV. Its predicted structure includes six transmembrane domains, a transient receptor potential (TRP) cation-channel domain, and an internal channel pore.[2] TRPML1 is believed to channel iron ions across the endosome/lysosome membrane into the cell and so its malfunction causes cellular iron deficiency.[3] It is important in lysosome function and plays a part in processes such as vesicular trafficking, exocytosis and autophagy.[4][5]
Ligands
- Agonists
See also
- transient receptor potential cation channel, mucolipin subfamily, member 2 (MCOLN2)
- transient receptor potential cation channel, mucolipin subfamily, member 3 (MCOLN3)
- mucolipidosis type IV
- TRPML
References
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External links
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