MNAT1

Template:Short description Template:Cs1 config Template:Infobox gene CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.

Function

Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'ménage à trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM]

Interactions

MNAT1 has been shown to interact with:

• Cyclin H,
• Cyclin-dependent kinase 7,
• Estrogen receptor alpha,
• MCM7,
• MTA1,
• P53, and
• POU2F1.

External links

• Template:PDBe-KB2