MAML1
Template:Short description Template:Infobox gene Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.[1][2][3]
Function
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.[3]
Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.
Interactions
MAML1 has been shown to interact with EP300[4][5] and NOTCH1.[1][6]
References
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Further reading
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