Lumiliximab
Template:Short description Template:Drugbox Lumiliximab is an IgG1k monoclonal antibody that targets CD23. It acts as an immunomodulator[1] and was awarded orphan drug status and fast track designation by the FDA.[2]
It was investigated in Phase II/III clinical trials for the treatment of chronic lymphocytic leukemia.[3][4] It has also been studied for use in allergic asthma. The drug is a chimeric antibody from Macaca irus and Homo sapiens.[1]
Lumiliximab was developed by IDEC Pharmaceuticals, which was acquired by Biogen. Clinical trials for CLL were terminated in 2010, and for allergic asthma in 2007.[2] Results published from the CLL clinical trial failed to meet primary endpoints.[5]
References
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- ↑ Clinical trial number NCT00801060 for "Evaluation of Safety and Efficacy of Fludarabine, Cyclophosphamide, and Rituximab (FCR) +/- Lumiliximab in Subjects With Previously Untreated Chronic Lymphocytic Leukemia (CLL)" at ClinicalTrials.gov
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