LSM-775
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LSM-775, also known as N-morpholinyllysergamide or as lysergic acid morpholide, is a derivative of ergine (lysergamide).[1] It is less potent than lysergic acid diethylamide (LSD) but is reported to have some LSD-like effects at doses ranging from 75 to 700 micrograms and a shorter duration.[2] LSM-775 may only produce weak or threshold psychedelic effects in humans.[3]
The drug is a potent full agonist of the serotonin 5-HT1A receptor and a potent partial agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors.[3] It does not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[3] However, LSM-775 can robustly increase head twitches if it is coadministered with the serotonin 5-HT1A receptor antagonist WAY-100635.[3] These findings indicate that serotonin 5-HT1A receptor activation suppresses the psychedelic-like effects of LSM-775.[3]
There are claimed to be fewer signs of cardiovascular stimulation and peripheral toxicity with LSM-775 compared to LSD.[2]Script error: No such module "Unsubst".
LSM-775 was first described in the scientific literature by Albert Hofmann and colleagues by 1955.[4]
See also
- Substituted lysergamide
- Lysergic acid pyrrolidide (LPD-824)
- Lysergic acid piperidide (LSD-Pip)
- Lysergic acid 2,4-dimethylazetidide (LA-SS-Az, LSZ)
References
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External links
- LSM-775 - Isomer Design
- LSM-775 - PsychonautWiki
- The Big & Dandy LSM-775 (Lysergic Acid Morpholide) Thread - Bluelight
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