LHX3
Template:Short description Template:Cs1 config Template:Infobox gene LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.[1][2][3]
Function
LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]
Clinical significance
Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.[3]
Interactions
LHX3 has been shown to interact with Ldb1.[4]
References
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Further reading
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External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.