LAIR1
Template:Cs1 config Template:Short description Template:Infobox gene Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[1][2] LAIR1 has also been designated as CD305 (cluster of differentiation 305).
Function
Script error: No such module "For". The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells.[3] Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[2]
Interactions
LAIR1 has been shown to interact with PTPN11[1][4] and PTPN6.[1][4][5][6][7]
References
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Further reading
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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