L-iditol 2-dehydrogenase

Template:Infobox enzyme In enzymology, a L-iditol 2-dehydrogenase (EC 1.1.1.14) is an enzyme that catalyzes the chemical reaction

L-iditol + NAD⁺ ⇌ L-sorbose + NADH + H⁺

Thus, the two substrates of this enzyme are L-iditol and NAD⁺, whereas its 3 products are L-sorbose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-iditol:NAD⁺ 2-oxidoreductase. Other names in common use include polyol dehydrogenase, sorbitol dehydrogenase, L-iditol:NAD⁺ 5-oxidoreductase, L-iditol (sorbitol) dehydrogenase, glucitol dehydrogenase, L-iditol:NAD⁺ oxidoreductase, NAD⁺-dependent sorbitol dehydrogenase, NAD⁺-dependent sorbitol dehydrogenase, and NAD⁺-sorbitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1K2W, 1PL6, 1PL7, and 1PL8.

References

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