L&S

L&S may refer to:

• L&S, commonly known as Leedy & Strupe, a company formed after the purchase of the Leedy Manufacturing Company
• Laverne & Shirley, an American television situation comedy
• Lilo & Stitch (franchise), a Disney franchise
  • Lilo & Stitch, a 2002 animated film and the first film in the franchise
  • Lilo & Stitch (2025 film), a live-action and CGI reimagining of the 2002 film
  • Lilo Pelekai and Stitch (Lilo & Stitch), the title character duo of the franchise
• the Lehigh and Susquehanna Railroad, a defunct railroad in Pennsylvania
• A Latin Dictionary, often referred to as "Lewis and Short"
• Lucas & Steve, a Dutch EDM duo