Kv channel interacting protein
Kv channel interacting proteins are members of a family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[1] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]
Members of this family include:
- KCNIP1, a protein that in humans is encoded by the KCNIP1 gene.[3][2]
- KCNIP2, a protein that in humans is encoded by the KCNIP2 gene.[3][2]
- KCNIP3, more commonly known as Calsenilin, a protein that in humans is encoded by the KCNIP3 gene.[4][5][2]
- KCNIP4, a protein that in humans is encoded by the KCNIP4 gene.[6][7][2]
References
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