KMT5A

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Template:Short description Template:Cs1 config Template:Infobox gene N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the KMT5A gene.[1][2][3][4] The enzyme is a histone methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine residue at position 20. S-Adenosyl methionine (SAM) is both the cofactor and the methyl group donor. The lysine residue is converted to N6-methyllysine residue.

File:Methyl lysine.svg
Leftmost: side chain of lysine. Next: N6-methyllysine side chain.

This histone modification is often abbreviated H4K20me1:

  • H4 - type of histone
  • K - symbol of lysine
  • 20 - position of the lysine residue modified
  • me - abbreviation for methyl group
  • 1 - number of methyl groups transferred

References

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Further reading

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