KIF18A
Template:Short description Template:Cs1 config Template:Infobox gene Kinesin family member KIF18A is a human protein encoded by the KIF18A gene.[1][2] It is part of the kinesin family of motor proteins.
Function
KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.[3]
KIF18a(-/-) knockout in mice results in complete sterility in males, but not females, due to abnormal development of the seminiferous tubules.[4] The mice were otherwise normal, suggesting KIF18a is not essential for cell divisions in non-germ cells.
Therapeutic Target
KIF18A has been considered as a cancer target because it is overexpressed in many cancer types and mouse studies suggest it is dispensable in somatic cells.[5] As such, small molecule inhibitors of KIF18A have been developed to block its activity. [5]
References
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Further reading
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External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Kinesin-like protein KIF18A
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