John W. Semple
Template:Short description Script error: No such module "Unsubst". John W. Semple is a Canadian Scientist formally at St. Michael's Hospital and a Professor of Pharmacology at the University of Toronto. He is currently a Professor of Transfusion Medicine at Lund University in Sweden. He was born in Windsor, Ontario in 1959 and received his PhD in Immunology at Queen's University at Kingston, Ontario. In 1991, Semple, along with John Freedman, discovered a T helper cell defect in patients with the bleeding disorder called immune thrombocytopenia (ITP).[1] ITP is a condition of having a low platelet count (thrombocytopenia) and most causes appear to be related to antibodies and T cells against platelets. Very low platelet counts can lead to a bleeding diathesis and purpura. The T cell defect was initially shown to be an exaggerated interleukin-2 response when T cells were cultured with platelets in vitro. Subsequently, this cytokine abnormality was shown by others to be responsible for many of the autoimmune mechanisms causing the disorder.).[2] [3] [4] [5] [6] The importance of understanding the T cell defects in ITP is that novel therapies aimed at these cells may significantly benefit patients with ITP.
References
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External links
- John Semple's laboratory homepage
- John Semple's biography at St. Michael's HospitalScript error: No such module "Unsubst".
- John Semple's biography at the University of Toronto
- Pages with script errors
- 1959 births
- Canadian medical researchers
- Canadian immunologists
- Living people
- Medical educators
- Queen's University at Kingston alumni
- People from Windsor, Ontario
- Scientists from Toronto
- Academic staff of the University of Toronto
- 20th-century Canadian scientists
- 21st-century Canadian scientists