Integrin beta 3

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Template:Short description Template:Cs1 config Template:Infobox gene Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.[1] CD61 is a cluster of differentiation found on thrombocytes.[2]

Structure and function

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.[3]

Role in endometriosis

Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.[4]

Interactions

CD61 has been shown to interact with PTK2,[5][6] ITGB3BP,[7][8] TLN1[9][10] and CIB1.[11]

See also

References

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Further reading

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External links

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