Indoxyl

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Indoxyl
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Molar mass 133.14728

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In organic chemistry, indoxyl is a nitrogenous substance with the chemical formula: C8H7NO.[1][2] Indoxyl is isomeric with oxindol and is obtained as an oily liquid.

Preparation

The Heumann indigo synthesis starts from anthranilic acid:

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Indoxyl-Synthese: Anthanilic acid (1) reacts with chloroacetic acid to give phenylglycine-o-carboxylic acid. When treated in molten sodium carbonate, the 2-Indoxycarboxylic acid (3) decarboxylates to give indoxyl (4) .

In nature indoxyl is derived from indican, which is a glycoside. The hydrolysis of indican yields β-D-glucose and indoxyl.

Indigo dye is a product of the mild oxidation of indoxyl.

Indoxyl can be found in urine and is titrated with Obermayer's reagent, which is a dilute solution of ferric chloride (FeCl3) in hydrochloric acid (HCl).[3]

References

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