ING4
Template:Short description Template:Infobox gene Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.[1][2]
Function
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.[2]
Interactions
ING4 has been shown to interact with EP300,[1] RELA[3] and P53.[1][4]
References
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Further reading
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.