IGSF8
Template:Short description Template:Cs1 config Template:Infobox gene Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.[1][2][3] IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.[4] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).[4] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,[4] and has been proposed as a potential therapeutic target in gliomas.[5] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.[4]
Cancer biomarker
In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.[5] IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.[6]
References
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Further reading
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External links
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