Hsien Wu
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Hsien Wu (Template:Zh; 24 November 1893 – 8 August 1959) was a Chinese biochemist and geneticist. He was the first to propose that protein denaturation was a purely conformational change, i.e., corresponded to protein unfolding and not to some chemical alteration of the protein.[1] This crucial idea was popularized later by Linus Pauling and Alfred Mirsky.[2]
Wu was born in Fuzhou, Fujian, China. He studied at the Massachusetts Institute of Technology (undergraduate), and then trained at Harvard University (graduate) under Otto Folin, developing the first small-volume (≥ 0.1-mL sample) assay for blood sugar (Folin-Wu method).[3] Wu then returned to China to a position at Peking Union Medical College, becoming head of the biochemistry department in 1924. At the end of that year, he married his research assistant Daisy Yen and would continue collaborating with her until his death in 1959.[4]
Wu left China in 1947 to reside in the United States; his wife and children joined him in 1949.
Wu's son, Ray J. Wu, became the Liberty Hyde Bailey Professor of Molecular Genetics and Biology at Cornell University, and developed the first method for sequencing DNA [5] and studying transgenic plants.
References
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- ↑ Script error: No such module "Citation/CS1". Preliminary reports were presented before the XIIIth International Congress of Physiology at Boston (19–24 August 1929) and in the October 1929 issue of the American Journal of Physiology.
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Further reading
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- 1893 births
- 1959 deaths
- 20th-century American biochemists
- American geneticists
- Biologists from Fujian
- Chemists from Fujian
- Chinese biochemists
- Chinese Civil War refugees
- Chinese emigrants to the United States
- Chinese geneticists
- Educators from Fujian
- Harvard University alumni
- Massachusetts Institute of Technology alumni
- Members of Academia Sinica
- Academic staff of Peking Union Medical College
- People from Fuzhou
- University of Alabama faculty