Hepatitis C alternative reading frame stem-loop
Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the hepatitis C virus (HCV) which is proposed to have an important role in regulating translation and repression of the viral genome.
The core protein-coding region of the hepatitis C virus (HCV) genome contains a +1 alternative reading frame (ARF) and two proposed phylogenetically conserved RNA helix-forming stem loop structures (IV and VII).[1] The proteins translated from the ARF appear to be translated during the normal viral life cycle but are not essential to virus replication.[1] The two predicted stem loops shown here (SLV and SLVI) are proposed to be important for HCV translation and repression; these stem loops are located downstream of the internal ribosome entry site (IRES) but their functional role is unknown.[1]
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