Hayashi rearrangement

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The Hayashi rearrangement is the chemical reaction of ortho-benzoylbenzoic acids catalyzed by sulfuric acid or phosphorus pentoxide.[1][2]

The Hayashi rearrangement
The Hayashi rearrangement

This reaction proceeds through electrophilic acylium ion attack with a spiro intermediate.[3][4]

Hayashi mechanism

References

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  3. The Hayashi Rearrangement of Substituted o-Benzoylbenzoic Acids Reuben B. Sandin, Russell Melby, Robert Crawford, and Donald McGreer J. Am. Chem. Soc. 1956 pp 3817 - 3819; Script error: No such module "CS1 identifiers".
  4. Name Reactions: A Collection of Detailed Reaction Mechanisms By Jie Jack Li Published 2003 Springer Template:ISBN

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