Hawkinsin

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Hawkinsin
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Molar mass 291.32 g/mol

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Hawkinsin (also known as 2-cystenyl-1,4-dihydroxycyclohexenylacetate[1]) is an amino acid, which is formed after detoxification of a reactive tyrosine metabolite (quinol acetate) by glutathione. Hawkinsin is ninhydrin positive (a common test to detect amino acids and proteins with a free -NH2 group).

It is found in elevated concentrations in the urine in hawkinsinuria, which is probably related to the depletion of glutathione and resulting high excretion of 5-oxoproline.[2]

References

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