Haplogroup L4

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Template:Short description Script error: No such module "Infobox".Template:Template other Haplogroup L4 is a human mitochondrial DNA (mtDNA) haplogroup. It is a small maternal clade primarily restricted to Africa.[1]

File:Frequency maps based on HVS-I data for haplogroups L4.png
Projected spatial frequency distribution for haplogroup L4.
File:Schematic tree of mtDNA haplogroups L4 and L6.png
Schematic tree of mtDNA haplogroup L4. Ages (in ka) indicated are maximum likelihood estimates obtained for the whole-mtDNA genome.

L4 is important in East Africa. The highest frequencies are in Tanzania among the Hadza at 60-83% and Sandawe at 48%.[2]

It has two branches, L4a and L4b. Subgroup L4a was formerly called L7 and considered a separate subclade of L3'4'7. It has been recognized as a subclade of L4, with L3 as its outgroup by Behar et al. (2008).[3] The parent clade L3'4 is to have emerged at 106–66 kya.[4] L4 is not much later than this, estimated at 87 kya by Fernandes et al. (2015).[5]

Phylogeny

The following phylogeny is based on van Oven and Kayser (2008).[6]

  • L3'4
    • L4
      • L4a (formerly known as L7), mutations: 195C, 3357, 5460, 10373, 11253, 11344, 11485, 12414, 13174, 14302, 16260.
        • L4a1
          • L4a1a
        • L4a2
      • L4b, mutations: 709, 3918.
        • L4b1
        • L4b2 (formerly known as L3g or L4g)
          • L4b2a
            • L4b2a1
            • L4b2a2
              • L4b2a2a
              • L4b2a2b
          • L4b2b

References

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  1. Haplogroups L4.
  2. Tishkoff, S. et al. 2007, History of Click-Speaking Populations of Africa Inferred from mtDNA and Y Chromosome Genetic Variation. Molecular Biology and Evolution 2007 24(10):2180-2195
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  5. Fernandes V, Triska P, Pereira JB, Alshamali F, Rito T, Machado A, et al. (2015) Genetic Stratigraphy of Key Demographic Events in Arabia. PLoS ONE 10(3): e0118625. Script error: No such module "CS1 identifiers".
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External links

Template:Sister project

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T

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