Hans Westerhoff
Template:Short description Script error: No such module "Distinguish". Template:Use dmy dates Script error: No such module "Template wrapper".Script error: No such module "Check for clobbered parameters". Hans Victor Westerhoff (born 14 January 1953)[1] is a Dutch biologist and biochemist who is professor of synthetic systems biology at the University of Amsterdam[2] and AstraZeneca professor of systems biology at the University of Manchester.[3] Currently he is a Chair of AstraZeneca and a director of the Manchester Centre for Integrative Systems Biology.[4][5]
Career
Westerhoff was born in Amsterdam, Netherlands. He was educated at the University of Amsterdam where he was awarded a PhD in 1983 for investigations of non-equilibrium thermodynamics and the control of biological thermodynamics supervised by Karel van Dam.[1] In 1996 he succeeded Ad Stouthamer as professor of microbiology at the Vrije Universiteit Amsterdam.[6]
Research
At the beginning of his career Westerhoff worked in the area of non-equilibrium thermodynamics in relation to biological energy transduction.[7][8] His work on this topic led to a book written with Karel Van Dam.[9]
After being a coauthor of one of the first experimental papers to stimulate interest in metabolic control analysis[10] and participating in the group that proposed a harmonized terminology,[11] Westerhoff moved progressively towards working on multi-enzyme systems as his major activity, starting with an analysis of the effect of enzyme activity on metabolite concentrations.[12] He published many papers in this area, of which one may note an analysis of the control of regulatory cascades,[13] analysqis of glycolytic oscilations in yeast,[14] and showing that the in vivo behaviour of Trypanosoma brucei agreed with the kinetic properties of the glycolytic enzymes.[15]
Westerhoff and colleagues discovered magainin in the African clawed frog which helps it fight against bacteria.[16] In December 1996 he and his group discovered a nitric-oxide reductase of Paracoccus denitrificans.[17]
In conjunction with many other workers Westerhoff used a community approach to construct a consensus yeast metabolic network[18] and subsequently applied the same approach to human metabolism.[19]
References
<templatestyles src="Reflist/styles.css" />
- ↑ a b Prof. dr. H.V. Westerhoff, 1953- at the University of Amsterdam Album Academicum website
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Template:Scopus
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
Script error: No such module "Check for unknown parameters".