HPB

HPB may refer to:

• Half Price Books, an American book retailer
• Harvard Papers in Botany, a scientific journal
• Health Promotion Board, a statutory board in Singapore for health promotion and disease prevention
• Helena Petrovna Blavatsky (1831–1891), theosophist, writer and traveler
• Hooper Bay Airport, in Alaska, United States (by IATA and FAA LID code)
• Hrvatska poštanska banka, largest Croatian-owned bank
• HPB (journal), journal of the International Hepato-Pancreato-Biliary Association
• Hexaphenylbenzene