HLA-DR17
| Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen | |
major histocompatibility complex, class II, DR17
| |
| Haplotypes groups | DRA*01:DRB1*0301 DRA*01:DRB1*0304 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
|
| Symbol(s) | HLA-DRAScript error: No such module "Unsubst". |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *0301 *0304
|
| Symbol(s) | HLA-DRB1Script error: No such module "Unsubst". |
| EBI-HLA | DRB1*0301 |
| EBI-HLA | DRB1*0304 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe (such as Western Ireland, N. Spain, Sardinia). DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18.
Serology
| DRB1* | DR17 | DR3 | DR18 | Sample |
| allele | % | % | % | size (N) |
| 0301 | 64 | 33 | 0 | 9698 |
| 0304 | 20 | 60 | 5 |
DR17 recognizes the DRB1*0301, *0304 alleles.
Disease associations
By serotype
DR17 is associated with non-chronic sarcoidosis,[2][3] infantile spasm/epilepsy,[4] rabies vaccine-induced autoimmune encephalomyelitis[5] and cardiovascular hypertrophy in subjects with arterial hypertension[6] People with DR17 show a tendency toward benzylpenicilloyl allergies.[7]
By allele
DRB1*0301: diabetes mellitus type 1,[8] myositis,[9] early onset Graves disease,[10] type 1 autoimmune hepatitis,[11] inflammatory inclusion body myositis.[12] In autoimmune hepatitis, DRB1*0301 correlates with more severe and difficult to treat disease.[13]
By haplotype
DRB1*0301:DQA1*05:DQB1*0201 is associated with diabetes mellitus type 1,[14] ovarian cancer,[15] non-thymomic myasthenia gravis,[16] idiopathic inflammatory myopathies,[17] non-cancer associated Lambert-Eaton myasthenic syndrome[18] and sarcoidosis [19]
By phenotype
The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome[20]
Genetic Linkage
DR17 Haplotypes
| ||||
| Serotypes | DRA | DRB1 | DRB3 | |
|---|---|---|---|---|
| DR17 | *0101 | *0301 | 0101 | |
| *0101 | *0301 | 0201 | ||
| Serotypes | DQA1 | DQB1 | DRB1 | |
| DR17(3)-DQ2(2.5) | *0501 | *0201 | *0301 | |
| Serotypes | HLA-A | HLA C | HLA B | DRB1 |
| A1-Cw7-B8-DR17(3) | *0101 | *0701 | *0801 | *0301 |
| A2-Cw7-B8-DR17(3) | *0201 | *0701 | *0801 | *0301 |
| A30-Cw5-B18-DR17(3) | *3002 | *0501 | *1801 | *0301 |
HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. DRB1*0301 is frequently within by the "Super-B8" or ancestral HLA haplotype:
A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201
This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1"
References
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- ↑ derived from IMGT/HLA
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