HLA-Cw7

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HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw7 is determined by the antibody recognition of α7 subset of HLA-Cw α-chains. For the serotype Cw7, the alpha chain are encoded by the HLA-Cw<templatestyles src="Template:Color/styles.css" />*07 allele group and the β-chain are encoded by B2M locus.[1] Cw7 and Cw<templatestyles src="Template:Color/styles.css" />*07 are almost synonymous in meaning. Cw7 is more common in West Africa to Ireland. Cw7 in Europe is part of the AH8.1 and HLA B7-DR15-DQ6 haplotypes. The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7.

Serotype

Cw7 recognition of some HLA Cw*07 gene products[2]
Cw*07 Cw7 Sample
allele % size (N)
*0701 74 304
*0702 68 976


Distribution

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References

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  2. Allele Query Form IMGT/HLA - European Bioinformatics Institute

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