HLA-A23
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HLA-A23 (A23) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α23 subset of HLA-A α-chains. For A23, the alpha, "A", chain are encoded by the HLA-A<templatestyles src="Template:Color/styles.css" />*23 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2301. A23 and A<templatestyles src="Template:Color/styles.css" />*23 are almost synonymous in meaning. A23 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A24.
A23 is common in Africa and regions of the Middle East, Mediterranean, and India than Europe, East Asia or the Americas.
Serotype
| A*23 | A23 | A<templatestyles src="Template:Color/styles.css" />24 | Sample |
| allele | % | % | size (N) |
| Template:HNLOA | 95 | <templatestyles src="Template:Color/styles.css" />1 | 5119 |
Allele
Haplotypes
A23-B7 is found in N.Afr. and S.Afr non-caucasians.
A23-B44 is found in Albania, Zimbabwe, Morocco, Spain and Danes.
A23-B58 is found in the !kung and Zaire.
Associated diseases
A*23:Cw*07 is associated with higher viral load in HIV[3]
References
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- ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
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