HIRA
Template:Short description Script error: No such module "about". Template:Infobox gene Protein HIRA is a protein that in humans is encoded by the HIRA gene.[1][2][3][4] This gene is mapped to 22q11.21, centromeric to COMT.[4]
Function
The specific function of this protein has yet to be determined; however, it has been speculated to play a role in transcriptional regulation and/or chromatin and histone metabolism.[4]
Research done by Salomé Adam, Sophie E. Polo, and Geneviève Almouzni indicate that HIRA proteins are involved in restarting transcription after UVC damage.[5] Function of HIRA gene can be effectively examined by siRNA knockdown based on an independent validation.[6]
Clinical significance
It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.[4]
Interactions
HIRA has been shown to interact with HIST1H2BK.[7]
References
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Further reading
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