HINT1
Template:Cs1 config Template:Short description Template:Infobox gene Histidine triad nucleotide-binding protein 1 also known as adenosine 5'-monophosphoramidase is an enzyme that in humans is encoded by the HINT1 gene.[1][2]
HINT1 hydrolyzes purine nucleotide phosphoramidates with a single phosphate group.[3] In addition, functions as scaffolding protein that modulates transcriptional activation.[4]
It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and microphthalmia-associated transcription factor (MITF) activity in human mast cells.[5][6] In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.[6][7]
See also
References
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Further reading
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