HERC5
Template:Short description Template:Infobox gene E3 ISG15–protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.[1][2]
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.[2] HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.[3][4][5]
Interactions
HERC5 has been shown to interact with NME2[6] and Cyclin E1.[1]
References
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