HARS
Template:Short description Script error: No such module "Distinguish". Script error: No such module "Distinguish". Template:Infobox gene Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene.[1][2]
Function
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins.[3] The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter.[1]
Clinical significance
The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.[3]
Interactions
HARS has been shown to interact with EEF1B2[4] and EEF1G.[4]
References
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Further reading
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