Glycineamide ribonucleotide
Glycinamide ribonucleotide (or GAR) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA.[1][2][3] The vitamins thiamine[4] and cobalamin[5] also contain fragments derived from GAR.[6]
File:Phosphoribosylamine.svg Phosphoribosylamine (PRA)
GAR is the product of the enzyme phosphoribosylamine—glycine ligase acting on phosphoribosylamine (PRA) to combine it with glycine in a process driven by ATP. The reaction, EC 6.3.4.13 forms an amide bond:[7]
- Template:Chem/link + Template:Chem/link + ATP → Template:Chem/link + ADP + Pi
The biosynthesis pathway next adds a formyl group from 10-formyltetrahydrofolate to GAR, catalysed by phosphoribosylglycinamide formyltransferase in reaction EC 2.1.2.2 and producing formylglycinamide ribotide (FGAR):[7]
- GAR + 10-formyltetrahydrofolate → FGAR + tetrahydrofolate
See also
References
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