Gideon Dreyfuss
Template:Short description Script error: No such module "Template wrapper".Script error: No such module "Check for clobbered parameters".
Gideon Dreyfuss is an American biochemist, the Isaac Norris Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine, and was an investigator of the Howard Hughes Medical Institute during 1990-2021. He was elected to the National Academy of Sciences in 2012.[1]
Dreyfuss received his Ph.D. in biological chemistry in 1978 from Harvard University and is a fellow of the American Academy of Arts and Sciences.
Research
Dreyfuss is interested in various projects studying the function and biogenesis of non-coding RNA and the proteins that interact with RNA. A primary research goal of his lab is to elucidate the function of Survival of Motor Neuron protein, SMN, which assembles a heptameric ring of Sm proteins on U snRNAs to form snRNPs that are essential components of the splicesome. Moreover, loss of functional SMN is directly linked to spinal muscular atrophy, a debilitating neurodegenerative disease that is characterize by the eventual death of motor neurons and muscular wasting. Dreyfuss has conducted research to understand the role of SMN in SMA pathology and using high throughput screening to discover potential therapeutics. The lab also studies the dynamic mechanism of RNA splicing, the RNA-binding proteins that determine exonic specificity, and snRNAs, that are important regulators of splicing and mRNA maturation.
Genes or Gene Functions Discovered
- eIF4A3[2]
- FXR1[3]
- FXR2[4]
- Gemin2 (Previously known as SIP1)[5]
- Gemin3/DDX20[6]
- Gemin4[7]
- Gemin5[8]
- Gemin6[9]
- Gemin7[10]
- hnRNPA1[11]
- RA33[12]
- hnRNPC[13]
- PTBP1[14]
- hnRNPK[15]
- hnRNPM[16]
- hnRNPR[17]
- hnRNPU[18]
- hnRNPQ[17]
- Y14[19]
- Magoh[20]
See also
References
<templatestyles src="Reflist/styles.css" />
- ↑ Penn Medicine Announcement, [1], May 3, 2012
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ a b Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
Script error: No such module "Check for unknown parameters".
External links
- Pages with script errors
- 21st-century American biochemists
- Harvard Graduate School of Arts and Sciences alumni
- Fellows of the American Academy of Arts and Sciences
- Howard Hughes Medical Investigators
- Living people
- Members of the United States National Academy of Sciences
- Hebrew University of Jerusalem alumni
- Massachusetts Institute of Technology alumni
- Members of the National Academy of Medicine