Gepefrine
Template:Short description Template:Drugbox Gepefrine, also known as 3-hydroxyamphetamine or α-methyl-meta-tyramine and sold under the brand names Pressionorm and Wintonin, is a sympathomimetic medication used as an antihypotensive agent which has been marketed in Germany.[1][2][3][4]
Pharmacology
Gepefrine is described as a sympathomimetic and antihypotensive agent.[5]
Chemistry
Gepefrine, also known as 3-hydroxy-α-methylphenethylamine or as 3-hydroxyamphetamine, is a substituted phenethylamine and amphetamine derivative.[5] It is used pharmaceutically as the (S)-enantiomer and as the tartrate salt.[5][1] Related compounds include meta-tyramine (3-hydroxyphenethylamine), 4-hydroxyamphetamine (norpholedrine), 3,4-dihydroxyamphetamine (α-methyldopamine), and metaraminol ((1R,2S)-3,β-dihydroxyamphetamine), among others.
History
Gepefrine was synthesized by 1968[5] and was introduced for medical use in Germany by 1981.[3]
Society and culture
Names
Gepefrine is the generic name of the drug and its INN.[5] Brand names of gepefrine include Pressionorm and Wintonin.[1][6]
Other drugs
Gepefrine is a known metabolite of amphetamine in rats.[4]
References
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